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Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). 
Retinoids should not be used on eczematous skin, as they may cause severe irritation. 
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Titration to doses above 90 mg daily is not recommended. 
Depending upon the cause, encephalopathy can occur at any age.